EEG in RODENTS

EEG Readouts Across Disease Models

At Ulysses Neuroscience Ltd., we provide advanced in vivo electrophysiology services using rodent EEG to support translational research and neuropharmacology programmes. Our European (HPRA) and North American (AAALAC) accredited platforms enable high-quality EEG studies in mice and rats, integrating behavioural, biomarker, PK/PD, and imaging readouts across a variety of disease models.

EEG Platforms Available

Changes in rodent EEG, such as REM suppression, spectral shifts, and oscillatory activity modulation, are mirrored in humans following treatment with CNS-active compounds. This makes rodent EEG a powerful pharmacodynamic biomarker to bridge preclinical and clinical development, support early go/no-go decisions, and de-risk novel neurotherapeutics.

Who will find this platform useful?
- Pharma & biotech companies developing CNS-active compounds
- Clients equiring translational EEG biomarkers to align preclinical results with clinical endpoints
- Partners seeking integrated EEG + behaviour + biomarker data to support IND-enabling studies

EEG Platforms Available

1. Pinnacle Wireless EEG (Mouse and Rat):
2 EEG + 1 EMG channels / Wireless Bluetooth transmission / Sampling rate: 512–1024 Hz / Adjustable electrode placement / Synchronized HD video recording / Real-time monitoring / Analysis software specialized on sleep and seizures

Wireless EEG/EMG Recording with the Pinnacle System in Mice.

2. Pinnacle Tethered EEG (Mouse and Rat):
2 EEG + 1 EMG channels / Continuous long-term tethered recordings / Sampling rate up to 20 kHz / Adjustable electrode placement / Synchronized HD video recording / Real-time monitoring / Analysis software specialized on sleep and seizures

3. DSI Telemetry EEG (Mouse and Rat):
2 biopotential channels (EEG/EEG or EEG/EMG) / 24/7 RF telemetry recording / Sampling up to 1 kHz / Also collects animal activity and body temperature data

Telemetry in rats.

4. Tainitec “TaiNi” EEG (Mouse):
Up to 16 recording channels / 1.5 g removable headmount (including battery) / Optimized for small mice / Sampling rate up to 20 kHz

Tainitec “TaiNi” EEG (Mouse)

Rodent EEG and Sleep Architecture Analysis

EEG and EMG telemetry recordings allow for automated, objective classification of vigilance states (Wake, NREM, REM). Spectral EEG analysis provides quantitative measures of drug-induced changes in brain oscillatory activity. These methods are essential for evaluating sedative/hypnotic activity, wake-promoting agents, and CNS engagement of psychoactive drugs.
• Full sleep-wake profiling
• Sleep latency and fragmentation
• qEEG analysis
• Hypnogram generation
• Repeated measures and crossover designs
• Integrated locomotor and temperature monitoring

Neuropsychiatric Models: Depression & Schizophrenia

Rodent Models: IFN-α model, Wistar-Kyoto rat, PCP-challenge
Auditory (Steady-State Response ASSR):
- Sensory gating readout disrupted by NMDA antagonists (e.g., PCP)
- Quantified by signal-to-noise ratio (SNR) and phase-locking factor (PLF)
- Drug rescue validation with investigational compounds
Mismatch Negativity (MMN):
- Measures pre-attentive auditory processing
- Detects changes in EEG response to deviant stimuli
- Useful for translational schizophrenia research

auditory steady-state response disruption by ketamine in rats

Psychedelics Research

Ulysses Neuroscience is fully licensed for Schedule I psychedelics and has a proven track record in evaluating the pharmacodynamic effects of classic and novel neuroplastogens. Our EEG-based assays provide key translational readouts:
• Gamma power enhancement
• REM sleep suppression
• Changes in spectral coherence and band-specific oscillations
• Dose–response profiles and time-course EEG shifts
• Combined EEG, behavioural, and biomarker analyses

wireless EEG recording with the Pinnacle System in mice dsi telemetry in rats

Why Partner with ULYSSES?

- Access to four complementary EEG platforms across mouse and rat
- Expertise in epilepsy, psychedelics, schizophrenia, and depression
- Synchronized HD video for behavioural correlation
- Seamless integration with preclinical and clinical biomarker pipelines
- Flexible study designs, expert scientific support, and full regulatory compliance
- Audited and approved by major pharmaceutical sponsors